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Testoviron depot 250 injection is a medicine used in the treatment of male hypogonadism caused due to low testosterone levels. It is a short dose oral preparation containing a hypogonadism-reducing mixture of testosterone enanthate and anabolic steroid. It has been given to men with low testosterone before and during testosterone replacement therapy (TRT). The combination of testosterone, anabolic steroids and androstenedione is believed to lead to a reduction in the risk of prostate cancer in men. Read More On This Topic hormone replacement therapy and hormonally active gonadotropins The effects of androgen replacement therapy are affected by the availability of androgens. This may be either via an aromatase inhibitor, which prevents the conversion of testosterone to dihydrotestosterone (DHT); or with androgen-dependent androgen receptor blockers (ADRBs), which block the activation of androgen receptors (ARs). Injections of hormones may also have effects at the plasma level (endocrine gland) that can be a determinant of effectiveness. In particular, the effect of androgen-dependent estrogen receptor modulators (AREs) increases with increasing androgen availability, and is not eliminated once the body no longer needs the androgen.[3] However, the use of AREs has been extensively evaluated for efficacy in preventing prostate cancer and other diseases.[4,5] Because the plasma levels of hormonally active gonadotropins (hCG, luteinizing hormone, follicle-stimulating hormone [FSH] and luteinizing hormone, progesterone) are influenced by both circulating androgens and by steroidal and mineralocorticoid hormone levels,[3,6] the presence of hormonally active gonadotropins does not appear to have an effect on the effectiveness of androgen replacement therapy.[3] The clinical significance of this phenomenon remains unclear, but it has been suggested that this may have an effect in relation to an increase in hCG.[7] Since the main goal of TRT involves the suppression of these hormonally active gonadotropins, TRT is frequently administered with the use of hormone replacement therapy (HRT), but only in men with an increased risk of prostate cancer or other serious illnesses.[1] The efficacy of androgen replacement therapy depends on factors such as the type of androgen, dose and duration of therapy, the timing of administration, and the specific type of the steroid.[10,11,12,13] The effect of the administration of androgens is not uniform across the body; for example Similar articles: